The research, published on 12 Feb, 2019 is done at University of Cambridge, UK.
The study done in KrasG12D driven mouse, co-relates the levels of cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA) with micro computed tomography (microCT). The study was able to make a cfDNA/ctDNA profile prior to adenoma-adenocarcinoma stage of tumor development.
This research sets up new opportunities to detect early stage lung cancer.
Lung Cancer is the currently the biggest cause of deaths due to cancer worldwide. It is largely due to the fact that it goes undetected in early stages and is hard to identify. Currently, CT scan and other markers are done to detect Lung Cancer. But, sometimes using CT routinely becomes impractical and expensive. Therefore, new cost effective methods needed to be developed.
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Liquid Biopsies have gained importance in detection of various types of cancers in past few years. The discovery of cfDNA and ctDNA paved way for new researches based of genetic identification of the diseases.
However, lot of work is still pending in association of cf/ctDNA with solid tumor cancers.
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With this research, new tests could be developed soon to identify lung cancer at an early stage and thereby increasing chances of survival for the patient.
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